Table 1 Number of protein agents included in the ABM at time 0(t0).

From: Heterogeneity in The Mechanical Properties of Integrins Determines Mechanotransduction Dynamics in Bone Osteoblasts

Molecular Agent

Numbers of agents at t0

Integrin

500

FAK

1000

Ras

1000

Raf

32

MEK

3400

Erk

2300

Runx2

24

mRNA - OCN

2

mRNA - OPN

2

mRNA - ALP

2

mRNA - BSP

2

OCN - Protein

1

OPN - Protein

1

ALP - Protein

1

BSP - Protein

1

complex

24

ribosome

600

Total number of agents

8892

  1. The numbers of proteins were derived from the concentrations of the corresponding proteins which were obtained from the literature (see Supplementary information (1) Initial parameters) The concentrations were converted into moles and then to total number of protein molecules using Avogadro’s number following the procedure outlined in Shuaib et al.69. The number of agents in active state and distribution in both the cytoplasm and nucleus are shown. The number of mRNA-agents and their corresponding ECM proteins are low at t0, however, with time their number significantly increase due to increased production as mechanotransduction propagates.
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