Figure 4 | Scientific Reports

Figure 4

From: In vivo multi-parametric manganese-enhanced MRI for detecting amyloid plaques in rodent models of Alzheimer’s disease

Figure 4The alternative text for this image may have been generated using AI.

In vivo QSM and Alizarin Red staining reveal thalamic calcifications in 5xFAD mice. (a, b) Quantitative susceptibility (χ) maps of a 5xFAD mouse (a) before (pre-Mn) and (b) after administration of MnCl2 (Post-Mn). Bilateral clusters in the thalamus were diamagnetic Pre-Mn but became paramagnetic Post-Mn (arrows). (c) A section from the same mouse, stained with Alizarin Red, shows that these thalamic clusters contain calcium and/or manganese. (d) An Alizarin-Red-stained section from a 5xFAD mouse without MR-visible thalamic clusters. Inset scale bars = 100 μm.

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