Figure 3 | Scientific Reports

Figure 3

From: Congenital adiponectin deficiency mitigates high-fat-diet-induced obesity in gonadally intact male and female, but not in ovariectomized mice

Figure 3The alternative text for this image may have been generated using AI.

Despite a similar degree of adiposity, HFD estrogen-deficient females exhibit enhanced insulin sensitivity relative to HFD males. After 16 weeks of LFD or HFD, mice (n = 10) were assessed metabolically by examining (A) fasting insulin levels, (B) a glucose tolerance test (GTT), (C) insulin response to the GTT, (D) insulin tolerance test (ITT), and (E) skeletal-muscle-specific insulin-induced AKT activation (n = 4–5). Data is presented as mean ± SE. Bar graphs not sharing a common letter are significantly different from one another (P < 0.05).

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