Figure 4 | Scientific Reports

Figure 4

From: Congenital adiponectin deficiency mitigates high-fat-diet-induced obesity in gonadally intact male and female, but not in ovariectomized mice

Figure 4The alternative text for this image may have been generated using AI.

Estrogen deficiency increases high-molecular-weight (HMW) adiponectin (APN), and APN deletion mitigates HFD-induced body fat accrual in gonadally intact males and females but not in ovariectomized females. After 16 weeks of LFD or HFD, (A) plasma was assessed for HMW APN in WT mice (n = 6–10). A subsequent 16-week HFD experiment was performed utilizing male and female (both intact and OVX) APN deficient mice (M and F APN−/−) and wildtype (WT) littermate controls (n = 19–46). The data is presented as follows, (B) body weight over the course of the study as well as % body weight change from baseline, (C) body fat %, (D) visceral fat accumulation, and (E) lean mass. Bar graphs not sharing a common letter or symbol are significantly different from one another (P < 0.05). ME = Main Effect.

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