Table 1 Estimated and calculated cocaine DST and estimated cocaine elimination half-life t1/2 in individual rats.
Rat | Baseline FR1 sessions | PR sessions | Post-PR FR1 sessions | |||||
|---|---|---|---|---|---|---|---|---|
Estimateda DST (µmol/kg) | Estimated t1/2 (s) | Calculatedb DST (µmol/kg) | Meanc t1/2 (s) | Calculated DST (µmol/kg) | Estimated DST (µmol/kg) | Estimated t1/2 (s) | Calculated DST (µmol/kg) | |
1 | 3.86 ± 0.49d | 479 ± 44 | 4.07 ± 0.19 | 482 | 3.67 ± 0.08 | 3.86 ± 0.71 | 485 ± 61 | 3.71 ± 0.16 |
2 | 4.12 ± 0.96 | 462 ± 85 | 3.82 ± 0.46 | 529 | 4.45 ± 0.12 | 5.23 ± 1.03 | 596 ± 81 | 5.52 ± 0.34 |
3 | 4.05 ± 0.34 | 489 ± 29 | 4.39 ± 0.09 | 523 | 3.64 ± 0.07 | 4.29 ± 0.42 | 556 ± 37 | 3.85 ± 0.10 |
4 | 5.15 ± 0.51 | 451 ± 33 | 4.62 ± 0.16 | 453 | 3.43 ± 0.16 | 4.93 ± 0.21 | 454 ± 12 | 3.52 ± 0.57 |
5 | 4.77 ± 0.45 | 559 ± 38 | 5.70 ± 0.13 | 585 | 4.37 ± 0.13 | 5.39 ± 1.09 | 611 ± 84 | 4.93 ± 0.19 |
6 | 4.61 ± 0.14 | 468 ± 11 | 3.86 ± 0.53 | 510 | 4.81 ± 0.16 | 5.29 ± 0.97 | 552 ± 73 | 5.20 ± 0.20 |
Mean | 4.43 ± 0.20 | 485 ± 16 | 4.41 ± 0.29 | 514 ± 18 | 4.06 ± 0.23 | 4.82 ± 0.25 | 542 ± 25 | 4.45 ± 0.35 |
