Table 3 Hepatic mRNA expression in ExHC and congenic rats.

From: Mutation in Smek2 regulating hepatic glucose metabolism causes hypersarcosinemia and hyperhomocysteinemia in rats

Symbol

Group

P

Cholesterol (−)

Cholesterol (+)

Strain

Chol

S x C

Congenic

ExHC

Congenic

ExHC

Sardh

1.00 ± 0.05

0.00 ± 0.00

1.12 ± 0.06

0.00 ± 0.00

 < 0.01

NS

NS

Dmgdh

1.00 ± 0.04

1.04 ± 0.02

1.00 ± 0.06

1.00 ± 0.05

NS

NS

NS

Bhmt

1.00 ± 0.12

0.78 ± 0.05

0.80 ± 0.06

0.57 ± 0.06

 < 0.01

 < 0.05

NS

Cbs

1.00 ± 0.05

1.16 ± 0.03

0.99 ± 0.09

1.15 ± 0.08

 < 0.05

NS

NS

Gnmt

1.00 ± 0.04

1.01 ± 0.03

1.00 ± 0.04

0.99 ± 0.07

NS

NS

NS

Gamt

1.00 ± 0.03

1.08 ± 0.06

1.02 ± 0.09

0.96 ± 0.04

NS

NS

NS

Pemt

1.00 ± 0.02

1.09 ± 0.05

0.85 ± 0.03

0.92 ± 0.09

NS

 < 0.01

NS

Pcyt1a

1.00 ± 0.06

0.97 ± 0.08

0.92 ± 0.12

0.98 ± 0.09

NS

NS

NS

Mthfr

1.00 ± 0.16

1.32 ± 0.16

0.85 ± 0.14

1.29 ± 0.19

 < 0.05

NS

NS

Smek2

1.00 ± 0.07a

0.21 ± 0.02b

1.32 ± 0.14a

0.19 ± 0.03b

 < 0.01

NS

 < 0.01

  1. Values are shown as means ± SEM. n = 6/group, Mean value of cholesterol (−) -congenic rats was set to 1.00. The Gusb gene was as the internal standard. Differences for each gene were detected by two-way ANOVA followed by Tukey–Kramer post-hoc test and were considered significant at P < 0.05. NS in the table is the abbreviation for “not significant”. a,b,cSignificant differences between groups with different letters at P < 0.05.
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