Table 4 Serum and hepatic parameters associated with sarcosine metabolism in ExHC and congenic rats.

From: Mutation in Smek2 regulating hepatic glucose metabolism causes hypersarcosinemia and hyperhomocysteinemia in rats

 

Group

P

Cholesterol (−)

Cholesterol (+)

Strain

Chol

S x C

Congenic

ExHC

Congenic

ExHC

Serum parameters

Sarcosine (μM)

52.2 ± 2.4

300 ± 17

41.4 ± 2.4

300 ± 12

 < 0.01

NS

NS

Betaine (μM)

74.9 ± 2.4

55.0 ± 1.8

76.6 ± 1.3

53.2 ± 0.8

 < 0.01

NS

NS

Homocysteine (μM)

15.0 ± 1.1

25.3 ± 2.8

16.7 ± 1.6

34.2 ± 2.3

 < 0.01

NS

NS

Liver parameter

Sarcosine (μg/g liver)

4.81 ± 0.45

11.4 ± 0.5

4.09 ± 0.60

10.4 ± 0.4

 < 0.01

 < 0.05

NS

  1. Values are shown as means ± SEM. n = 6/group, S × C, strain × cholesterol interaction. *P, two-way ANOVA. NS in the table is the abbreviation for “not significant”.
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