Figure 3
From: Neuronal glutathione loss leads to neurodegeneration involving gasdermin activation
Comprehensive analyses of GCLC-KO mouse brains. (A) Proteomic analyses were performed using protein samples from the cortices of 4-month-old WT and GCLC-KO. Values shown in the table represent the relative expression level of each protein in GCLC-KO/WT. Proteins whose expression levels were > twofold greater in GCLC-KO, in addition to being significant at the p < 0.05 level, are listed. Yellow and cyan highlights proteins whose mRNA are abundant in microglia or astrocytes, respectively. The mRNA expression of each protein was referred to Mousebrain.org (http://mousebrain.org/genesearch.html). (B) Protein levels of cytokines in 4-month-old WT and GCLC-KO were determined by cytokine array. Values shown in the graph represent the mean relative expression level of cytokines in GCLC-KO/WT (n = 4; *p < 0.05).
