Figure 4 | Scientific Reports

Figure 4

From: CENPF knockdown inhibits adriamycin chemoresistance in triple-negative breast cancer via the Rb-E2F1 axis

Figure 4The alternative text for this image may have been generated using AI.

The Rb-E2F1 axis mediates the regulation of Chk1 expression by CENPF. (A) Colocalization of CENPF and Rb in MDA-MB-231 and MDA-MB-231/ADR cells. (B,C) Western blotting detected the binding protein of immunoprecipitated endogenous CENPF (B) or Rb (Rb). (D) Co-IP and western blotting demonstrated that CENPF and E2F1 compete for Rb binding. (E,F) Western blot analysis of the effect of CENPF knockdown on E2F1 expression.

Back to article page