Figure 5
From: Remdesivir increases mtDNA copy number causing mild alterations to oxidative phosphorylation
Lung is unaffected by remdesivir treatment. (a) Representative western blots for subunits for oxidative phosphorylation complexes in lung. GAPDH is used as a loading control. Full-length membrane images can be found in Figure S5a-d. (b) Quantification of lung western blots in (a) for subunits for oxidative phosphorylation complexes normalized to GAPDH. (c) Representative western blot for TFAM in lung. GAPDH is used as a loading control. (d) Quantification of lung western blots in (c) for TFAM normalized to GAPDH. (e) Representative hematoxylin and eosin staining images of lung collected 30 days post-treatment. Scale bar = 400 μm for left images. Scale bar = 100 μm for right images. RDV n = 2, vehicle n = 4. Error bars ± SEM. n = 5/group. One dot equals an individual animal.
