Figure 6 | Scientific Reports

Figure 6

From: Saponins from Allii Macrostemonis Bulbus attenuate atherosclerosis by inhibiting macrophage foam cell formation and inflammation

Figure 6The alternative text for this image may have been generated using AI.

A proposed model for the role of SAMB in regulating atherosclerosis. On one hand, SAMB can downregulate the translation and transcription of lipid transporters CD36 and SR-A1, thereby inhibiting the phagocytosis of oxidized low-density lipoprotein by macrophages, reducing foam cell formation and plaque development. On the other hand, SAMB can suppress the expression of inflammatory factors by inhibiting the NF-κB/NLRP3 signaling pathway, resulting in decreased macrophage infiltration in plaques.

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