Fig. 2
CHIP is associated with greater biological aggressiveness of the disease. (A) Histogram plot showing BMPCs ≥ 60% in CHIP (red) carriers compared with those without abnormalities (blue). Data are mean ± SD; ns = not significant (Kolmogorov–Smirnov test). (B) Regression analysis correlating VAF in BMSCs (CD138NEG) and PBMCs across the entire cohort. R = 0.97; p < 0.0001(unpaired t-test). (C) Violin plot displaying β2-microglobulin, 24 h protein urine, creatinine, serum FLC k, eGFR and hemoglobin levels between samples with CHIP (red) and those without (blue). Statistically significant differences are marked by asterisk. Data are mean ± SD; *p = 0.05, **p = 0.03, ***p = 0.02 (Kolmogorov–Smirnov test). (D) MOSAIC plot related to Person’s chi-squared test, showing the relationship between CHIP and ISS and R-ISS stages (I-III).
