Table 3 Risk factors for iodinated contrast Media-Induced adverse drug reactions in the two Groups.

From: Comparison of ioversol and iodixanol related adverse drug reactions in cerebrovascular interventional procedures

 

Iodixanol(n = 435)

P

Value

Ioversol(n = 413)

P

Value

Patients who experienced ADRs (n = 123)

Patients who did not experience ADRs (n = 312)

Patients who experienced ADRs (n = 143)

Patients who did not experience ADRs (n = 270)

Age (years) (mean)

60.11 ± 13.59

61.85 ± 12.13

0.192

59.08 ± 14.10

62.95 ± 11.52

0.005*

Female sex

29 (23.6)

75 (24.0)

0.919

45 (31.5)

56 (20.7)

0.016*

BMI (kg/m2)

23.91 ± 3.49

24.24 ± 2.91

0.332

23.83 ± 3.25

24.15 ± 3.26

0.354

Abnormal liver functiona

11 (8.9)

40 (12.8)

0.258

16 (11.2)

32 (11.9)

0.841

Allergic diseaseb

17(13.8)

19 (6.1)

0.008*

12 (8.4)

23 (8.5)

0.965

Hypertensive disease

84 (68.3)

214 (68.6)

0.952

92 (64.3)

193 (71.5)

0.135

Diabetes

34 (27.6)

85 (27.2)

0.933

37 (25.9)

71 (26.3)

0.926

Atrial fibrillation

4 (3.3)

7 (2.2)

0.546

3 (2.1)

6 (2.2)

0.924

Coronary heart disease

10 (8.1)

32 (10.3)

0.499

7 (4.9)

27 (10.0)

0.073

Cholesterol level (mmol/L)

3.70 ± 1.04

3.79 ± 1.08

0.401

3.91 ± 1.07

3.73 ± 0.91

0.076

Triglyceride level (mmol/L)

1.47 ± 0.73

1.64 ± 1.01

0.097

1.67 ± 0.92

1.54 ± 0.67

0.157

Homocysteine level (µmol/L)

20.92 ± 17.16

21.31 ± 17.16

0.835

19.93 ± 16.58

18.75 ± 13.01

0.468

Creatinine level (µmol/L)

70.35 ± 17.66

68.39 ± 17.07

0.285

67.52 ± 17.14

70.23 ± 16.53

0.119

Medications

Metformin hydrochloride

18 (14.6)

49 (15.7)

0.780

19 (13.3)

43 (15.9)

0.475

Beta-blockers

14 (11.4)

28 (9.0)

0.444

11 (7.7)

14 (5.2)

0.309

Previous exposure to ICM

42 (34.1%)

89 (28.5%)

0.250

35 (24.5%)

79 (29.3%)

0.301

Procedural characteristics

Volume of ICM used (mL)

163.93 ± 36.15

161.71 ± 39.74

0.591

172.64 ± 49.85

164.97 ± 41.89

0.098

Intraoperative hypertension

90 (73.2)

210 (67.9)

0.287

93 (65.0)

203 (75.2)

0.029*

Severe cerebral vascular stenosisc, d

55 (44.7)

141 (45.2)

0.928

86 (60.1)

104 (38.5)

0.001*

  1. Note.—aAanine aminotransferase > 40 U/L or aspartate aminotransferase > 40 U/L.bAllergic disease was defined as any of the following conditions alone or in combination: bronchial asthma, allergic rhinitis, atopic dermatitis, urticaria, drug allergy (antibiotics, NSAID, sulfa, or pyrine), or food allergy. cSevere cerebral vascular stenosis was defined as a stenosis rate > 70%. dThe cerebral vasculature includes the common carotid artery, internal carotid artery, subclavian artery, vertebral artery, basilar artery, anterior cerebral artery, middle cerebral artery, and posterior cerebral artery. * p value < 0.05. BMI = body mass index, ICM = iodinated contrast media, ADRs = adverse drug reactions.
Back to article page