Fig. 3 | Scientific Reports

Fig. 3

From: The effect of coadministration of D156844 and AR42 (REC-2282) on the survival and motor phenotype of mice with spinal muscular atrophy

Fig. 3The alternative text for this image may have been generated using AI.

Oral administration of AR42 augmented the D156844-induced increase in the onset of loss in body mass of SMNΔ7 SMA mice. Kaplan-Meier onset of body mass loss plot for SMNΔ7 SMA mice receiving either vehicle (dotted blue line; n = 17), 3 mg/kg/d D156844 (solid gray line; n = 13), 10 mg/kg/d AR42 (dashed orange line; n = 16) or a combination of 10 mg/kg/d AR42 and 3 mg/kg/d D156844 (solid brown line; n = 15). Treatment of SMNΔ7 SMA mice began at PND04.

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