Table 2 Segment-specific slopes for iron measures in years before and after the FMP.

From: Accelerated increase in ferritin levels during menopausal transition as a marker of metabolic health

  

Segment-specific slope (SE)

P value of coefficient

P value for pairwise difference in segment-specific slopes

Overall P value for differences in segment-Specific Slopes

P value for likelihood ratio Test (Linear vs. Stepwise)

Variable

n

Segment 1: FMP ≤ -1

Segment 2: -1 < FMP ≤ 1

Segment 3: FMP > 1

Segment 1

Segment 2

Segment 3

Segment 1 vs. 2

Segment 1 vs. 3

Segment 2 vs. 3

Hemoglobin

18,908

0.02(0.007)

0.204(0.012)

-0.051(0.009)

0.007

< 0.0001

< 0.0001

< 0.0001

< 0.0001

< 0.0001

< 0.0001

< 0.0001

Iron

18,908

0.825(0.237)

3.419(0.469)

-0.56(0.297)

5.00E-04

< 0.0001

0.0598

< 0.0001

< 0.0001

< 0.0001

< 0.0001

< 0.0001

TIBC

18,908

-1.431(0.319)

-6.354(0.444)

-0.796(0.352)

< 0.0001

< 0.0001

0.0238

< 0.0001

< 0.0001

< 0.0001

< 0.0001

< 0.0001

Ferritin

18,908

1.945(0.381)

20.732(0.542)

9.354(0.444)

< 0.0001

< 0.0001

< 0.0001

< 0.0001

< 0.0001

< 0.0001

< 0.0001

< 0.0001

Transferrin Saturation

18,908

0.384(0.086)

1.422(0.158)

-0.074(0.105)

< 0.0001

< 0.0001

0.4798

< 0.0001

< 0.0001

< 0.0001

< 0.0001

< 0.0001

  1. The observation periods of the participants were categorized into three specific time periods relative to the FMP: more than 1 year before the FMP (pre-FMP), within 1 year of the FMP (around FMP), and more than 1 year after the FMP (post-FMP). These time periods correspond to segments 1, 2, and 3, respectively. To assess the differences in slope across the three segments, piecewise linear mixed models were used and adjusted for age, education, marital status, parity, and iron supplementation. The fitness of the linear mixed and piecewise linear mixed models were compared by evaluating their AIC values.
  2. FMP final menstrual period, SE standard error, TIBC total iron binding capacity.
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