Fig. 4
From: Morphological alterations of peridroplet mitochondria in human liver biopsy
Comparative analysis of peridroplet and cytoplasmic mitochondrial morphology between patients with simple steatosis and metabolic dysfunction-associated steatohepatitis (MASH). (a) Representative transmission electron microscopy (TEM) images (scale bar = 2 μm) depicting six morphological parameters (area, perimeter, circularity, roundness, aspect ratio, and solidity) of peridroplet mitochondria in patients with simple steatosis and MASH. (b) Corresponding scatter plots and TEM images (scale bar = 2 μm) for cytoplasmic mitochondria in the same patient groups. Statistical significance was determined by the Mann–Whitney U test (ns, not significant; * p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001). MASH, metabolic dysfunction-associated steatohepatitis; TEM, transmission electron microscopy.
