Table 2 Comparison of plasma AA metabolite levels (pmol/µL) between control and sarcopenia groups in the discovery cohort (144 men and 72 women).

From: Amino acid metabolites as potential circulating biomarkers for sarcopenia

 

Men (n = 144)

Women (n = 72)

Control (n = 72)

Sarcopenia (n = 72)

p

Control (n = 36)

Sarcopenia (n = 36)

p

BCAAs

Ile

296.8 [257.9;345.9]

274.3 [217.1;310.1]

0.007

246.8 [210.4;288.1]

244.6 [211.2;266.9]

0.910

Leu

443.8 [404.7;495.2]

380.0 [328.6;457.6]

3.11E-04

376.9 ± 85.6

360.7 ± 69.8

0.939

Val

2840.0 [2580.2;3179.3]

2504.2 [2243.7;2910.2]

0.001

2578.0 [2258.2;2887.7]

2490.4 [2197.2;2671.8]

0.820

EAAs

Met

60.2 [53.0;70.2]

55.3 [47.2;64.3]

0.040

53.0 [45.5;57.2]

50.1 [45.9;56.8]

0.849

Phe

75.0 [66.9;81.8]

69.5 [61.3;76.9]

0.028

70.0 [63.6;77.1]

67.3 [58.2;72.8]

0.419

Trp

105.2 ± 18.7

97.1 ± 22.5

0.049

97.9 ± 26.2

95.9 ± 18.8

0.983

Non-EAAs

α-AAA

3.7 [2.9;4.7]

3.0 [2.4;3.6]

0.003

3.0 [2.3;3.7]

2.5 [2.2;3.1]

0.419

Glu

122.1[89.4;159.4]

96.1[68.2;139.1]

0.023

113.7 ± 42.4

84.0 ± 32.1

0.042

MetO

1090.1 [963.8;1199.3]

998.4 [888.1;1110.8]

0.023

1000.6 [886.5;1121.2]

955.3 [865.7;1033.5]

0.820

  1. Data are presented as mean ± SD and median [IQR].
  2. p: P value by Student’s t-test or the Mann–Whitney U test after adjusting for multiple testing corrections using the false discovery rate (FDR) method.
  3. Abbreviations: AAs, amino acids; α-AAA, alpha-aminoadipic acid; BCAAs, branched-chain amino acids; EAAs, essential amino acids; Glu, glutamate; Ile, isoleucine; IQR, interquartile range; Leu, leucine; Met, methionine; MetO, methionine sulfoxide; Non-EAAs, non-essential amino acids; Phe, phenylalanine; SD, standard deviation; Trp, tryptophan; Val, valine.
  4. Bold numbers indicate statistically significant values.
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