Fig. 11

(A) Biopsy specimen removed eight months post implantation: well structured muscle bundles arranged in a fusiform element (colored in red) in a surround of healthy and compact connective (colored in blue) close to the fabric of the S&S device (X). AM 25X—(B) Biopsy sample removed from the 3D scaffold of the S&S device 3 months after implantation. The figure shows several nervous elements (colored in brown) close to the TPE fiber of the scaffold (X). NSE 25X—The microphotograph left below highlights in a nervous element higher magnification. NSE 200X—(C) Biopsy sample excised 6 months after implantation of the S&S device. The low magnification image shows several nervous elements (blue arrows) close to the TPE fiber of the scaffold (X). NSE 25x—The microphotograph right above details one nerve showing fully mature axon components and a healthy myelin sheath. NSE 200X—(D) Biopsy specimen excised 4 weeks after implantation showing several vascular structures (white elongated oval spots) in the stage of endothelial development close to the structure of the S&S device (X). VEFG 100X.