Fig. 4
From: Auditory genotype-phenotype correlation of patients with variants in STRC
Age-related change in mean pure tone audiometry (PTA) thresholds by genotype. (A-C) Mean PTA thresholds (average of 0.5, 1, 2, and 4 kHz) of the better ear are plotted as a function of age. Solid lines represent best-fit linear regression models, and dashed lines indicate 95% confidence intervals. No statistically significant age-related progression was observed in any group. (A) Better ear thresholds in all patients (n = 19). Regression: Y = − 0.03·X + 39.80 (95% CI: − 0.37 to 0.30, r² = 0.002, p = 0.84). (B) Better ear thresholds in patients with homozygous STRC/CATSPER2 gene deletions (n = 10). Regression: Y = 0.21·X + 35.83 (95% CI: − 0.38 to 0.80, r² = 0.076, p = 0.44). (C) Better ear thresholds in patients with other STRC variants (n = 9). Regression: Y = − 0.29·X + 45.32 (95% CI: − 0.77 to 0.18, r² = 0.237, p = 0.18).
