Table 7 Dosimetric comparison of clinical plan, AutoPlan, and rapidplan in external (n = 20) validation cohorts. All plans were generated with jaw tracking.
From: Personalized intensity modulation radiation therapy auto-planning for esophageal cancer
Parameter | Clinical plan (CP) | Autoplan (AP) | RapidPlan (RP) | p value | |||
|---|---|---|---|---|---|---|---|
CP vs AP | AP vs RP | CP vs RP | |||||
PTV | V100% | 95 ± 0.0 | 95 ± 0.0 | 95 ± 0.0 | -- | -- | -- |
Dmax[%] | 109.9 ± 5.3 | 109.5 ± 2.7 | 109.4 ± 2.9 | 0.610 | 0.610 | 1.000 | |
Lung | V5[%] | 43.5 ± 12.1 | 39.4 ± 11.3 | 42.1 ± 11.7 | 0.001 | 0.006 | 0.883 |
V10 [%] | 28.0 ± 8.8 | 25.2 ± 8.6 | 27.9 ± 8.8 | 0.010 | 0.002 | 0.845 | |
V20[%] | 14.1 ± 6.7 | 12.6 ± 5.7 | 12.6 ± 5.8 | 0.120 | 0.920 | 0.250 | |
Dmean[Gy] | 8.3 ± 2.4 | 7.8 ± 2.4 | 8.0 ± 2.4 | 0.001 | 0.099 | 0.254 | |
Spinal Cord | Dmax[Gy] | 37.4 ± 3.6 | 37.9 ± 1.3 | 34.5 ± 3.1 | 0.510 | 0.031 | 0.001 |
Heart | V30 [%] | 25.9 ± 17.2 | 29.6 ± 20.5 | 26.9 ± 21.4 | 0.221 | 0.025 | 0.609 |
Dmean [Gy] | 18.9 ± 9.6 | 18.6 ± 10.1 | 18.2 ± 10.2 | 1.000 | 0.047 | 0.047 | |
Liver | V30[%] | 1.4 ± 2.4 | 1.4 ± 2.3 | 1.6 ± 2.4 | 0.990 | 0.800 | 0.710 |
Dmean[Gy] | 2.2 ± 2.4 | 2.2 ± 2.3 | 2.2 ± 2.3 | 0.250 | 0.990 | 0.190 | |
Kidney_L | V20 [%] | 0.1 ± 0.2 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.970 | 1.000 | 0.970 |
Dmean[Gy] | 0.6 ± 0.9 | 0.6 ± 0.7 | 0.6 ± 0.6 | 0.020 | 0.709 | 0.002 | |
Kidney_R | V20[%] | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 1.000 | 1.000 | 1.000 |
Dmean [Gy] | 0.4 ± 0.4 | 0.4 ± 0.5 | 0.4 ± 0.5 | 1.000 | 0.510 | 0.560 | |
CI | 0.84 ± 0.07 | 0.85 ± 0.03 | 0.83 ± 0.04 | 0.990 | 0.250 | 0.190 | |
HI | 1.06 ± 0.01 | 1.07 ± 0.01 | 1.06 ± 0.01 | 0.000 | 0.004 | 0.709 | |
MU | 747.3 ± 239.9 | 675.4 ± 109.6 | 675.8 ± 110.1 | 0.990 | 0.990 | 0.950 | |
