Table 2 Univariate and multivariable Fine-Gray subdistribution regression analyses of the risk of acute exacerbation in patients across the derivation, validation, and combined whole cohorts.

From: A novel, non-spirometric “BMP index” for predicting severe adverse outcomes in fibrosing interstitial lung diseases

BMP index

Derivation cohort (n = 218)

Validation cohort (n = 148)

Whole cohort (n = 366)

Crude sdHR of AE1 (95% CI)

P value

Crude sdHR of AE1 (95% CI)

P value

Crude sdHR of AE1 (95% CI)

P value

0

Ref.

Ref.

Ref.

Ref.

Ref.

Ref.

1

0.90 (0.33–2.46)

0.84

4.01 (1.12–14.30)

0.032

1.74 (0.83–3.65)

0.15

2

5.31 (2.42–11.67)

< 0.001

9.99 (2.82–35.40)

< 0.001

6.61 (3.38–12.94)

< 0.001

3

19.76 (9.05–43.15)

< 0.001

40.59 (12.49–131.90)

< 0.001

25.73 (13.71–48.30)

< 0.001

BMP index

Adjusted sdHR of AE2 (95% CI)

P value

Adjusted sdHR of AE2 (95% CI)

P value

Adjusted sdHR of AE2 (95% CI)

P value

0

Ref.

Ref.

Ref.

Ref.

Ref.

Ref.

1

0.71 (0.25–2.06)

0.53

2.76 (0.77–9.90)

0.12

1.40 (0.66–2.99)

0.38

2

4.22 (1.90–9.36)

<0.001

5.04 (1.34–18.99)

0.017

4.63 (2.32–9.25)

< 0.001

3

11.86 (5.32–26.43)

<0.001

18.73 (5.45–64.43)

< 0.001

13.80 (7.08–26.88)

< 0.001

  1. 1Values were derived from univariate Fine-Gray subdistribution hazard regression analysis controlling for the competing risk of death.
  2. 2Values were derived from multivariable Fine-Gray subdistribution hazard regression analysis, which accounted for the competing risk of death and also adjusted for GAP stages, the Charlson comorbidity index, and echocardiographic probabilities of pulmonary hypertension. AE, acute exacerbation; GAP, gender-age-physiology; Ref., the reference group in the determination of subdistribution hazard ratios; sdHR, subdistribution hazard ratio; 95% CI, 95% confidence interval.
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