Fig. 8
From: MiR-142-3p targets the CXCL12/WNT/β-catenin pathway to regulate the stemness of breast cancer cells
SOX2 can regulate the drug resistance, proliferation, migration and EMT of MCF 7/PTX cells (a) The expression of SOX2 protein in MCF 7/PTX cells and MCF 7 cells was examined using Western blot analysis. (b) Western blot experiment was conducted to compare the effects of three interference fragments (sh1, sh2, sh3). (c) Western blot analysis was employed to assess the impact of SOX2 on the levels of drug resistance proteins in MCF 7/PTX cells. (d) The effects of SOX2 on the proliferation of MCF 7/PTX cells were evaluated using CCK8 assays. (e-f) The influence of SOX2 on the migration of MCF 7/PTX cells was assessed through wound healing and transwell assays. (g) Western blot analysis was conducted to investigate the effect of SOX2 on the expression of EMT-related proteins. (*P < 0.05, **P < 0.01, ***P < 0.001).
