Fig. 5
Correlation between NIA permeation (P) and electrical skin membrane resistance (Rmem) in logarithmic coordinates (in accordance with Eq. 3), including both human skin and EpiDerm model. (A) All data (n = 43, where each point representing a pair of P and Rmem values for a single skin membrane (regression line: logP = − 0.98 ± 0.14log Rmem–3.2, R2 = 0.56). (B) Subset (n = 18) for pH 5.0 (regression line: logP = − 0.94 ± 0.18log Rmem–3.3, R2 = 0.63). (C) Subset (n = 25) for pH 7.4 (regression line: logP = − 1.09 ± 0.22log Rmem2.9, R2 = 0.52).
