Abstract
Accurate diagnosis and assessment of the severity of skin diseases are essential for appropriate clinical treatment. This paper proposes a multi-stage intelligent diagnosis framework based on deep learning to assist dermatologists in decision-making. The framework firstly adopts LeNet-5 convolutional neural network for preliminary classification of common skin diseases, and then performs secondary classification of disease severity and progression for selected representative conditions. Through manual annotation, clinical prior knowledge, including the predilectable location of the lesion, is incorporated into the framework to improve the reliability of the diagnosis. All images were preprocessed with grayscale conversion to reduce visual variability. Experimental results show that the performance of the proposed framework is stable and reliable, especially in the recognition tasks of disease severity and stage with obvious clinical manifestations. This hierarchical diagnostic strategy is consistent with routine clinical workflows and shows potential as an adjunct to precision diagnosis and treatment planning in dermatology.
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Acknowledgements
This study was especially grateful to engineer Xinyu Li for his assistance in revising the manuscript, to Dr. Yuliang Hu (Dermatology) for his diagnostic suggestions and patient imaging data, and to Dr. Liu, an anonymous physician from a clinic in Neijiang, Sichuan for his support.
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The study protocol was approved by the Institutional Ethics Committee (approval number: NJYY-LL-2026-0228). Patient-related image data were anonymized to protect personal privacy.
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Chen, J., Cai, F., Ding, W. et al. Research on multi-stage deep learning based intelligent diagnosis of skin diseases and skin medicine diagnosis community construction concept. Sci Rep (2026). https://doi.org/10.1038/s41598-026-53742-7
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DOI: https://doi.org/10.1038/s41598-026-53742-7


