Fig. 2: Graphical comparison of IHC HER2, total HER2, and phosphorylated HER2 Y1248 determined through proteomic analysis.
From: Proteomics based selection achieves complete response to HER2 therapy in HER2 IHC 0 breast cancer
Correlation of total HER2 (left) and phosphorylated HER2 Y1248 (Right) with central IHC determined HER2 in HR+/HER2−, HR−/HER2+, HR+/HER2−, HR−/HER2− (a: total breast cancer reference population N = 744 pts) and HR-/HER2- (b: TNBC breast cancer referent population N = 165, bottom). Centrally determined IHC scores are shown: Red = IHC 3+, Yellow = IHC 2+, Green = IHC 1+, and Light Blue = IHC 0). a: pie charts representing the percentage of each HER2 IHC determination at specific RPPA ranges (gray dashed line) are shown for RPPA total HER2 (left) and phosphorylated HER2 Y1248 (right). The value for the case patient is shown as a red line for reference and context.
