Fig. 5: Representative images of the top 5 patches of ALK-positive adenocarcinomas.
From: Evidential deep learning-based ALK-expression screening using H&E-stained histopathological images
The tumors show a cribriform pattern (a, e), papillary pattern (b), or solid pattern (c, d, f). Some tumors have intracellular mucin (b, f). Tumors with hepatoid (exhibiting abundant cytoplasm, round nuclei, and conspicuous nucleoli) features are found (d). Generally, the regions of tumor cells show higher association (lime color) with ALK-positive on Grad-CAM (a–c, e, and f) except the tumor with hepatoid feature (d). The intratumoral stroma and mucin showed different degrees of association with ALK positivity. Circles indicate areas of tumor cells, and the others point to tumor stromal areas.
