Fig. 4: Wheel running in mice promotes physiological remodeling in the heart in coordination with spatial upregulations of CITED4.

a Representative DT-MRI images of helicity changes from the endocardium to epicardium between sedentary and exercised mice in cohort 1. b–d Helicity differences within the septum, lateral wall and averaged across all AHA sections. e Magnified representative images of DAPI and CITED4 within the septal and lateral wall regions within exercised and sedentary mice. f–h CITED4 signal in sedentary and exercised mice within the septum, lateral wall and averaged across all AHA sections. Unpaired two-tailed t-test. *P < 0.05, **P < 0.01, ***P < 0.001. Data are presented min to max. Within each box, horizontal black and red lines denote median values; boxes extend from the 25th to the 75th percentile of each group’s distribution of values.