Fig. 2: Gln175His and Arg177* are major contributors to the gene burden association of ANGPTL7 with IOP. | Communications Biology

Fig. 2: Gln175His and Arg177* are major contributors to the gene burden association of ANGPTL7 with IOP.

From: ANGPTL7, a therapeutic target for increased intraocular pressure and glaucoma

Fig. 2: Gln175His and Arg177* are major contributors to the gene burden association of ANGPTL7 with IOP.The alternative text for this image may have been generated using AI.

Association of Gln175His (a) and Arg177* (c) variants in ANGPTL7 with IOP, effect measured in standard deviation units, in individuals of European descent. b, d Boxplots representing IOPg in the UK Biobank across genotypes. b Gln175His heterozygous and homozygous carriers have a 0.8-mmHg and 4.1-mmHg lower median IOPg, respectively, compared to non-carriers. d Arg177* heterozygous carriers have a 1.4-mmHg lower IOPg compared to non-carriers. GHS Geisinger DiscovEHR, UKB UK Biobank, MAF Minor allele frequency.

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