Fig. 3: Mir125b-2m−/p− mice showed impaired hippocampus-related behaviors.
From: Mir125b-2 imprinted in human but not mouse brain regulates hippocampal function and circuit in mice
Bar graphs showing differences in behavioral tests from Mir125b-2m−/p− mice and their corresponding wild-type controls (Mir125b-2m+/p+). a Alternation rate (%) of the Y-maze test: spontaneous (left) and rewarded (right). b Results of novel object recognition test (NORT). Training phase (left panels): time spent with the same two objects (O1) for 2 h (top) and 24 h (bottom). Test phase (right panels): time spent with two different objects (O1 and O2) for 2 h (top) and 24 h (bottom). c Bar graph showing the number of entries into the center of the field for Mir125b-2m+/p+ and Mir125b-2m−/p− mice during the open field test. d Bar graph showing time spent in the light zone for Mir125b-2m+/p+ and Mir125b-2m−/p− mice during the light-dark box test. Student’s t-test, two-tailed. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. Mir125b-2m+/p+, n = 12 mice; Mir125b-2m−/p−, n = 9 mice. All data are the mean ± s.e.m.
