Extended Data Fig. 8: High PEPD serum levels is associated with AT insulin resistance and drives the differences between the pharmacologic and genetic animal models of PEPD down-regulation. | Nature Metabolism

Extended Data Fig. 8: High PEPD serum levels is associated with AT insulin resistance and drives the differences between the pharmacologic and genetic animal models of PEPD down-regulation.

From: Dysregulation of macrophage PEPD in obesity determines adipose tissue fibro-inflammation and insulin resistance

Extended Data Fig. 8: High PEPD serum levels is associated with AT insulin resistance and drives the differences between the pharmacologic and genetic animal models of PEPD down-regulation.The alternative text for this image may have been generated using AI.

a. Heat map representing the four factors extracted through EFA performed among mice fed chow. The columns report the factors loadings of the observed variables. b, c. Pearson correlation matrix between ScW and GnW ECM remodelling markers, PEPD serum levels and metabolic parameters in the mice from the four models (PEPD, CBZ-Pro, BMT and PEPD-injection) fed chow (b) or chow+HFD (c). Metabolic/fibro-inflammatory parameters from the four animal models (that is CBZ-Pro, PEPD, BMT and PEPD-injection) were plotted according to factor 1 and 3.

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