Extended Data Fig. 9: LXRαW441R/W441R mice do not develop fibrotic liver injury on a High Fat, low-cholesterol diet. | Nature Metabolism

Extended Data Fig. 9: LXRαW441R/W441R mice do not develop fibrotic liver injury on a High Fat, low-cholesterol diet.

From: Damaging mutations in liver X receptor-α are hepatotoxic and implicate cholesterol sensing in liver health

Extended Data Fig. 9: LXRαW441R/W441R mice do not develop fibrotic liver injury on a High Fat, low-cholesterol diet.The alternative text for this image may have been generated using AI.

Age-matched (16–17 weeks) Wild-type (N = 9, WT) or homozygous knock-in mice (N = 8, Hom) fed a 45% High-fat diet (HFD) with low ( ~ 0.02% cholesterol) cholesterol content. An older group of homozygous knock-in mice (2 x 21 weeks, 4 x 31 weeks old) fed a high cholesterol western diet (0.2% cholesterol, WD) for the same period of time, in parallel, were included as a positive control A: Serum ALT measured in Error bars represent mean ± SEM after 4 weeks of western diet. B: Representative Haematoxylin and Eosin (H + E) and Picosirius red stained (PSR) liver sections from these animals euthanised after 8 weeks of western diet.

Source data

Back to article page