Extended Data Fig. 6: Transcription factor (TF) enrichment analysis of metagene factors.
From: Hypergraph factorization for multi-tissue gene expression imputation
For every metagene (n=50) and factor (n=98), we performed Gene Set Enrichment Analysis using the corresponding gene loadings of HYFA’s encoder (Methods) and TF gene sets from the TRRUST database of transcription factors (Enrichr library: TRRUST_Transcription_Factors_2019). (a) Top enriched TFs, ranked by the total number of metagene factors in which the TFs were enriched (FDR < 0.05). (b) Circos plot of the top 9 enriched TFs (outer layer). The angular size is proportional to the number of enrichments. The second layer (bar plot) depicts the factor IDs where the TF was enriched, ranging from 0 (lowest bar) to 98 (highest bar). The third layer shows the corresponding metagene IDs (blue dots) of the enriched metagene factors, increasing monotonically within the same factor. The edges in the middle connect TFs whenever they are both enriched in the same factor (FDR < 0.05). (c, d) Distribution of the GATA1 false discovery rates in factor 69 (FDR < 0.05 in 28/50 metagenes) and an arbitrary factor (enriched in 0/50 metagenes).
