Extended Data Fig. 7: GO Biological Process enrichment analysis of metagene factors.
From: Hypergraph factorization for multi-tissue gene expression imputation
For every metagene (n=50) and factor (n=98), we performed Gene Set Enrichment Analysis using the corresponding gene loadings of HYFA’s encoder (Methods) and Gene Ontology gene sets (GO Biological Process, version of 2021) (Enrichr library: GO_Biological_Process_2021). (a) Top enriched signaling GO terms, ranked by the total number of metagene-factors in which the terms were enriched (FDR < 0.05). (b, c) FDR distribution of the Type-I Interferon signaling pathway in factor 18 (FDR < 0.05 in 12/50 metagenes) and an arbitrary factor (enriched in 0/50 metagenes).
