The Global Neurodegeneration Proteomics Consortium (GNPC) is a multifaceted open-data resource of about 250 million protein measurements for biomarker discovery and mechanistic research across several neurodegenerative diseases. By harmonizing large-scale proteomic datasets with clinical data across 23 studies, the GNPC offers an important resource for neurodegenerative disease research and a template for large-scale data sharing in other scientific endeavors.
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Acknowledgements
The authors thank the participants and their families, as well as the cohorts, institutions and their dedicated staff who helped to create this consortium. We thank all GNPC members for contributing substantially to the development of the version 1 harmonized dataset, and the GNPC Scientific Steering Committee for contributing to the review and refinement of this Comment.
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S.L. holds shares in Johnson & Johnson received through his employment, and in Akrivia Health a company he cofounded and acts as a scientific author for. F.I. declares no competing interests.
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Lovestone, S., Imam, F. & on behalf of the Global Neurodegeneration Proteomics Consortium (GNPC) Scientific Steering Committee. The GNPC provides a proteomic resource for biomarker discovery and mechanistic insight in neurodegenerative disease. Nat Aging 5, 1181–1185 (2025). https://doi.org/10.1038/s43587-025-00920-3
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DOI: https://doi.org/10.1038/s43587-025-00920-3
