Fig. 4: Illustration of thresholds applied for defining and grading liver steatosis.
From: Diagnosing and defining MASLD in people living with chronic hepatitis B
Criteria are shown using A histopathology and B non-invasive assessment by controlled attenuation parameter (CAP) measurement, based on (i) American guidelines (based on a single centre study with 119 patients, excluding people living with chronic hepatitis B (PLWHB)47,49, (ii) European guidelines (based on meta-analysis data including multi-aetiology liver disease, including over 1000 PLWHB52), and (iii) by meta-analysis data with viral-hepatitis specific thresholds49. Colours indicate grades of steatosis: Green—S0, Yellow—S1, Light red—S2, Dark red—S3. AUC area under the receiver operator curve, CAP controlled attenuation parameter, CHB chronic hepatitis B, CHC chronic hepatitis C, S1 mild hepatic steatosis (consistent with fat deposition in 5–33% of hepatocytes); S2—moderate hepatic steatosis (fat deposition in 34–66% of hepatocytes), S3—severe steatosis (fat depostion in >66% of hepatocytes).
