Fig. 1: TS1 pigs recapitulate cardiac human phenotype.
a, Representative ECG traces of WT (top, in blue) and TS1 (bottom, in red) pigs showing marked QTc interval prolongation in TS1. b, Box plot shows the distribution of QTc interval in n = 27 WT animals (minimum 419 ms, median 482 ms, IQR: 469–500 ms, maximum 514 ms) and n = 28 TS1 animals (minimum 521 ms, median 586 ms, IQR: 552–615 ms, maximum 657 ms). Statistical analysis was conducted using the two-tailed Mann–Whitney U-test (P < 0.0001). c, Example of lethal ventricular arrhythmias in TS1 pigs, triggered by PVCs (red asterisks). d, Documentation of a sequence of three PVCs on the 24-h Holter ECG (above) and a PVC-triggered episode of VF recorded by implantable cardioverter defibrillator (below) in a young patient with TS1.
