Fig. 3: Cross-reactivity of individual IgG and IgA B-cell clones towards SARS-CoV-2 and seasonal human coronaviruses. | npj Viruses

Fig. 3: Cross-reactivity of individual IgG and IgA B-cell clones towards SARS-CoV-2 and seasonal human coronaviruses.

From: SARS-CoV-2 crossreactive B-cells outnumber seasonal coronavirus spike-specific clones at the end of the COVID-19 pandemic

Fig. 3: Cross-reactivity of individual IgG and IgA B-cell clones towards SARS-CoV-2 and seasonal human coronaviruses.The alternative text for this image may have been generated using AI.

a The clonal IgG cross-reactivity patterns of CD19+ B-cells cultured at limiting concentration were determined using B-cell profiling. The mean fluorescent intensity (MFI; range: 1000–65,350) of each clone for each antigen is indicated for pre-pandemic (blue shades) and end-pandemic individuals (red shades). The clone number, total number of reactive clones per antigen, as well as the color-coded donor ID and number of donors with reactive clones, are indicated. b Clonal cross-reactivity patterns of IgA clones are plotted similarly.

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