In yeast, the phosphatase Cdc14 controls mitotic exit. Here the authors show that mammalian CDC14B antagonizes CDK1, to keep the deubiquitinase USP9X unphosphorylated and inactive, and that Wilms’ tumor protein 1 is a substrate for active USP9X that directs mitosis-specific transcription to regulate mitotic survival.
- Michael Dietachmayr
- Abirami Rathakrishnan
- Florian Bassermann
