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Showing 1–13 of 13 results
Advanced filters: Author: Amy Torkelson Clear advanced filters

  • Massively parallel reporter assays promise rapid in vivo characterization of enhancer AAVs. Here, through systematic testing, authors uncover pervasive technical and biological noise, including chimeric AAV species, that exposes fundamental limitations in pooled enhancer screening.

    • Avery C. Hunker
    • John K. Mich
    • Jonathan T. Ting
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-16

  • A high-resolution transcriptomic and epigenomic cell-type atlas of the developing mouse visual cortex from embryonic to postnatal development is presented, providing a real-time dynamic molecular map associated with individual cell types and specific developmental events.

    • Yuan Gao
    • Cindy T. J. van Velthoven
    • Hongkui Zeng
    ResearchOpen Access
    Nature
    Volume: 647, P: 127-142

  • Long-distance migration and dispersion is a common characteristic of nearly all classes of telencephalic GABAergic neurons, which diversify extensively after birth in the cortex and striatum, but show limited postnatal changes in the septum, preoptic area and pallidum.

    • Cindy T. J. van Velthoven
    • Yuan Gao
    • Hongkui Zeng
    ResearchOpen Access
    Nature
    Volume: 647, P: 143-156

  • Combined patch clamp recording, biocytin staining and single-cell RNA-sequencing of human neurocortical neurons shows an expansion of glutamatergic neuron types relative to mouse that characterizes the greater complexity of the human neocortex.

    • Jim Berg
    • Staci A. Sorensen
    • Ed S. Lein
    ResearchOpen Access
    Nature
    Volume: 598, P: 151-158

  • A millimetre-scale bioresorbable optoelectronic system with an onboard power supply and a wireless, optical control mechanism is developed for general applications in electrotherapy and specific uses in temporary cardiac pacing.

    • Yamin Zhang
    • Eric Rytkin
    • John A. Rogers
    Research
    Nature
    Volume: 640, P: 77-86

  • A comprehensive single-cell RNA sequencing study delineates cell-type-specific transcriptomic changes in the brain associated with normal ageing that will inform the investigation into functional changes and the interaction of ageing and disease.

    • Kelly Jin
    • Zizhen Yao
    • Hongkui Zeng
    ResearchOpen Access
    Nature
    Volume: 638, P: 182-196

  • The affected cellular populations during Alzheimer’s disease progression remain understudied. Here the authors use a cohort of 84 donors, quantitative neuropathology and multimodal datasets from the BRAIN Initiative. Their pseudoprogression analysis revealed two disease phases.

    • Mariano I. Gabitto
    • Kyle J. Travaglini
    • Ed S. Lein
    ResearchOpen Access
    Nature Neuroscience
    Volume: 27, P: 2366-2383

  •  A transcriptomic cell-type atlas of the whole adult mouse brain with ~5,300 clusters built from single-cell and spatial transcriptomic datasets with more than eight million cells reveals remarkable cell type diversity across the brain and unique cell type characteristics of different brain regions. 

    • Zizhen Yao
    • Cindy T. J. van Velthoven
    • Hongkui Zeng
    ResearchOpen Access
    Nature
    Volume: 624, P: 317-332

  • An examination of motor cortex in humans, marmosets and mice reveals a generally conserved cellular makeup that is likely to extend to many mammalian species, but also differences in gene expression, DNA methylation and chromatin state that lead to species-dependent specializations.

    • Trygve E. Bakken
    • Nikolas L. Jorstad
    • Ed S. Lein
    ResearchOpen Access
    Nature
    Volume: 598, P: 111-119

  • The BRAIN Initiative Cell Census Network has constructed a multimodal cell census and atlas of the mammalian primary motor cortex in a landmark effort towards understanding brain cell-type diversity, neural circuit organization and brain function.

    • Edward M. Callaway
    • Hong-Wei Dong
    • Susan Sunkin
    ResearchOpen Access
    Nature
    Volume: 598, P: 86-102