IL-17A signaling contributes to the pathogenesis of psoriasis via the production of inflammatory mediators. Here, by integrating in vitro experiments and in vivo analysis, the authors report a non-canonical IL-17-KLK8 axis that induces lactate accumulation and histone lactylation, ultimately driving keratinocyte hyperactivation, and highlight the therapeutic value of targeting this lactylation-driven pathway for psoriasis treatment.
- Xuecheng Shen
- Wenxuan Qiao
- Qiang Xu
