Notch signaling is required for T cell development. Georgopoulos and colleagues identify an enhancer that specifically boosts Notch1 expression in early thymic progenitors through the DN3 stage, expanding the less committed multipotent progenitors and preparing these cells for faithful lineage commitment.
- Mariko Kashiwagi
- Daniela Salgado Figueroa
- Katia Georgopoulos
