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Showing 1–4 of 4 results
Advanced filters: Author: Derek Laver Clear advanced filters

  • Insect toxins with tandem repeats of neurotoxin domains have been found with enhanced receptor avidity. Here, the authors describe a bivalent toxin from remipede venom that targets ryanodine receptors, a rare target for animal venoms.

    • Michael J. Maxwell
    • Chris Thekkedam
    • Mehdi Mobli
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-13

  • Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited arrhythmia syndrome that is often difficult to treat. Hiroshi Watanabe and coworkers now show that flecainide, an approved drug known to inhibit sodium channels, is able to target the underlying cause of CPVT by inhibiting calcium release through the ryanodine receptor. Flecainide prevented arrhythmia in a mouse model of CPVT and was also effective when tested in two individuals with CPVT.

    • Hiroshi Watanabe
    • Nagesh Chopra
    • Björn C Knollmann
    Research
    Nature Medicine
    Volume: 15, P: 380-383

  • The Kir potassium channels are known to operate and gate without a major conformational change. Here, the authors identify the permeation gate of Kir channels as a steric plug within the conduction pathway, describing how tightly associated anionic lipids pushing into fenestrations in the pore walls engage with the plug to operate the gate.

    • Ruitao Jin
    • Sitong He
    • Jacqueline M. Gulbis
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-11

  • The transition between conducting and non-conducting states of K+ channels has been explained by conformational changes at the intracellular entrance to the conduction pathway. Here authors demonstrate that control over K+ currents in Kir channels is not explained by the canonical pore-gating model, as conduction is not impaired by a constricted inner helix bundle.

    • Katrina A. Black
    • Sitong He
    • Jacqueline M. Gulbis
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-13