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Showing 1–2 of 2 results
Advanced filters: Author: Elad Elkayam Clear advanced filters

  • Garg et al. determined structures of human Fructosamine-3-kinase (FN3K) bound with different nucleotide analogues and a small molecule sugar mimic substrate. Accompanied by biochemical analysis, they revealed features of the enzyme important for kinase activity and sugar moiety dynamics, providing mechanistic insights into FN3K function.

    • Ankur Garg
    • Kin Fan On
    • Leemor Joshua-Tor
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • This Progress article describes recent studies showing that the human lipopolysaccharide sensor caspase-4 activates pro-IL-18 and causes vascular leakage by inducing pyroptosis in endothelial cells. Structural studies have uncovered allosteric sites of caspase-4 that might be effective drug targets to inhibit vascular leakage.

    • Elad Elkayam
    • Francois G. Gervais
    • Judy Lieberman
    Reviews
    Nature Reviews Immunology
    Volume: 25, P: 558-568