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Showing 1–3 of 3 results
Advanced filters: Author: Fan-Tso Chien Clear advanced filters

  • In eukaryotic cells, DNA is wrapped around histones to form nucleosomes, which are further organized into the 30-nm chromatin fiber. A single-molecule study with homogeneous chromatin fibers now shows that the chromatin fiber behaves as a simple spring, stretching up to three times in response to pulling, a behavior indicative of a one-start helix structure. Linker histones stabilize the fiber but do not make it stiffer.

    • Maarten Kruithof
    • Fan-Tso Chien
    • John van Noort
    Research
    Nature Structural & Molecular Biology
    Volume: 16, P: 534-540

  • The mechanism underlying the dissemination of diffuse large B-cell lymphoma (DLBCL) is unclear. Here, the authors show that STAT3 controls amoeboid migration in DLBCL via the transcriptional activation of RHOH, which then releases RhoA from RhoGDIγ-mediated suppression, or via regulating microtubule dynamics to activate RhoA.

    • Yi-Ru Pan
    • Chih-Cheng Chen
    • Muh-Hwa Yang
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-16