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The impact of long-term seismic coupling on fault-based seismic hazard models: insights from the central Apennines (Italy)

Deborah Di Naccio
Cinzia Di Lorenzo
Michele M. C. Carafa
ResearchOpen Access24 Oct 2025
npj Natural Hazards

Volume: 2, P: 1-15
A targetable type III immune response with increase of IL-17A expressing CD4⁺ T cells is associated with immunotherapy-induced toxicity in melanoma

Dimitriou et al. perform multiomic profiling of patients with melanoma experiencing immunotherapy-associated toxicity and identify a targetable role for type III-associated immune responses with an increase in CD4⁺ T cells expressing IL-17A.

Florentia Dimitriou
Phil F. Cheng
Reinhard Dummer
ResearchOpen Access29 Aug 2024
Nature Cancer

Volume: 5, P: 1390-1408
Antitumoral effect of a nonviral interleukin-2 gene therapy is enhanced by combination with 5-fluorouracil

Jeffrey S Bishop
Nikolyn M Thull
Federica Pericle
Research13 Sept 2000
Cancer Gene Therapy

Volume: 7, P: 1165-1171
Dynamic thresholding and tissue dissociation optimization for CITE-seq identifies differential surface protein abundance in metastatic melanoma

CITE-seq analysis in healthy skin, and both primary vs. metastatic melanoma samples suggests practical considerations of different skin dissociation protocols and dynamic thresholding of antibody signals for biomarker discovery.

Ulrike Lischetti
Aizhan Tastanova
Mitchell P. Levesque
ResearchOpen Access10 Aug 2023
Communications Biology

Volume: 6, P: 1-16
Live slow-frozen human tumor tissues viable for 2D, 3D, ex vivo cultures and single-cell RNAseq

Fresh vs. slow-frozen tissues from various malignancies are compared for the establishment of 2D, 3D and ex vivo cultures, as well as for scRNAseq analysis, and found to be comparable and suitable for cancer research.

Gaetana Restivo
Aizhan Tastanova
Mitchell P. Levesque
ResearchOpen Access28 Oct 2022
Communications Biology

Volume: 5, P: 1-12

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The impact of long-term seismic coupling on fault-based seismic hazard models: insights from the central Apennines (Italy)

A targetable type III immune response with increase of IL-17A expressing CD4+ T cells is associated with immunotherapy-induced toxicity in melanoma

Antitumoral effect of a nonviral interleukin-2 gene therapy is enhanced by combination with 5-fluorouracil

Dynamic thresholding and tissue dissociation optimization for CITE-seq identifies differential surface protein abundance in metastatic melanoma

Live slow-frozen human tumor tissues viable for 2D, 3D, ex vivo cultures and single-cell RNAseq

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A targetable type III immune response with increase of IL-17A expressing CD4⁺ T cells is associated with immunotherapy-induced toxicity in melanoma