Nature Search

Construction of dual-cofactor artificial metalloenzymes for synergistic and enantiodivergent catalysis of Michael addition reactions

A dual-cofactor artificial metalloenzyme is developed, incorporating a biotinylated nickel complex and a Strep-tagged peptide catalyst in adjacent streptavidin-binding sites. This synergistic artificial metalloenzyme achieves enantiodivergent Michael addition reactions with tunable stereochemistry and high turnover numbers across diverse ketone and enal substrates.

Weijin Wang
Xinjian Ji
Xile Hu
Research20 Nov 2025
Nature Synthesis

Volume: 5, P: 420-432
Discovery and characterization of a marine bacterial SAM-dependent chlorinase

Alessandra S Eustáquio
Florence Pojer
Bradley S Moore
Research02 Dec 2007
Nature Chemical Biology

Volume: 4, P: 69-74
Pyridomycin bridges the NADH- and substrate-binding pockets of the enoyl reductase InhA

Crystal structures reveal that the antitubercular compound pyridomycin blocks binding of the NADH cofactor to the fatty acid synthesis enzyme InhA while also blocking the lipid substrate–binding pocket.

Ruben C Hartkoorn
Florence Pojer
Stewart T Cole
Research01 Dec 2013
Nature Chemical Biology

Volume: 10, P: 96-98
Antibody–peptide conjugates deliver covalent inhibitors blocking oncogenic cathepsins

Cathepsins are relevant therapeutic targets in cancer and other diseases. Here, the authors developed a different approach to block the activity of cathepsins in specific cellular contexts by combining non-natural peptide inhibitors with antibodies, enhancing therapeutic efficacy while reducing side effects.

Aaron Petruzzella
Marine Bruand
Elisa Oricchio
Research29 May 2024
Nature Chemical Biology

Volume: 20, P: 1188-1198
High-affinity peptides developed against calprotectin and their application as synthetic ligands in diagnostic assays

A peptide was developed that binds to calprotectin, a marker of major inflammatory disorders, and found to be suited for diagnostic tests. The use of synthetic peptides in assays is of great interest due to their high precision, robustness and low price.

Cristina Díaz-Perlas
Benjamin Ricken
Christian Heinis
ResearchOpen Access17 May 2023
Nature Communications

Volume: 14, P: 1-14
Lansoprazole is an antituberculous prodrug targeting cytochrome bc₁

Tuberculosis control is threatened by the continued emergence of drug-resistant strains. Here, Rybniker et al. screen a library of FDA-approved drugs and identify a gastric proton pump inhibitor that also has antituberculosis activity and targets the bacterial cytochrome bc1complex.

Jan Rybniker
Anthony Vocat
Stewart T. Cole
ResearchOpen Access09 Jul 2015
Nature Communications

Volume: 6, P: 1-8
Patient-derived monoclonal antibody neutralizes SARS-CoV-2 Omicron variants and confers full protection in monkeys

A potent mAb shows promise in monkeys either alone or in a combination therapy for either prophylaxis or treatment of infection with SARS-CoV-2 Omicron BA.1, BA.1.1 and BA.2.

Craig Fenwick
Priscilla Turelli
Giuseppe Pantaleo
ResearchOpen Access25 Jul 2022
Nature Microbiology

Volume: 7, P: 1376-1389
Btk SH2-kinase interface is critical for allosteric kinase activation and its targeting inhibits B-cell neoplasms

Constitutive Btk signaling drives several B-cell cancers. Here the authors demonstrate key allosteric intramolecular interactions between the SH2 domain and the kinase domain of Btk, and propose an alternative approach for inhibition of both wild-type and tyrosine kinase inhibitor-resistant Btk.

Daniel P. Duarte
Allan J. Lamontanara
Oliver Hantschel
ResearchOpen Access08 May 2020
Nature Communications

Volume: 11, P: 1-15
Palmitoylated acyl protein thioesterase APT2 deforms membranes to extract substrate acyl chains

Acyl protein thioesterase APT2 interacts with membranes via its charged β-tongue, becomes palmitoylated by ZDHHC3/7 and deforms the bilayer to extract substrate acyl chains. APT2 deacylation leads to its membrane release and degradation.

Laurence Abrami
Martina Audagnotto
F. Gisou van der Goot
Research11 Mar 2021
Nature Chemical Biology

Volume: 17, P: 438-447
Selective inhibition of STAT3 signaling using monobodies targeting the coiled-coil and N-terminal domains

STAT3 is an attractive therapeutic target but its homology with other STAT proteins complicates the development of selective inhibitors. Here, the authors develop monobodies with high affinity and selectivity for STAT3 and show that they can interfere with cellular STAT3 activity.

Grégory La Sala
Camille Michiels
Oliver Hantschel
ResearchOpen Access17 Aug 2020
Nature Communications

Volume: 11, P: 1-16
De novo development of proteolytically resistant therapeutic peptides for oral administration

Target-specific peptides that resist gastrointestinal proteases when delivered orally into mice can be generated via the evolution and selection of double-bridged peptides through in vitro protease-resistant-phage display.

Xu-Dong Kong
Jun Moriya
Christian Heinis
Research11 May 2020
Nature Biomedical Engineering

Volume: 4, P: 560-571
Author Correction: Internalization and vacuolar targeting of the brassinosteroid hormone receptor BRI1 are regulated by ubiquitination

Sara Martins
Esther M. N. Dohmann
Grégory Vert
Amendments and CorrectionsOpen Access17 May 2021
Nature Communications

Volume: 12, P: 1-2
A rheostat mechanism governs the bifurcation of carbon flux in mycobacteria

Microbes survive in dynamic environments by modulating their intracellular metabolism. Here, the authors reveal that mycobacteria employ a rheostat-like mechanism to regulate carbon flux between the oxidative TCA cycle and the glyoxylate shunt during glucose-acetate diauxic shift.

Paul Murima
Michael Zimmermann
John D. McKinney
ResearchOpen Access24 Aug 2016
Nature Communications

Volume: 7, P: 1-13
Internalization and vacuolar targeting of the brassinosteroid hormone receptor BRI1 are regulated by ubiquitination

Ubiquitination of cargo proteins regulates endocytosis in yeast and mammalian cells, however the extent to which this applies to plants is less clear. Martins et al. show that both internalization and vacuolar targetting of the Arabidopsisbrassinosteroid receptor BRI1 are regulated by ubiquitination.

Sara Martins
Esther M. N. Dohmann
Grégory Vert
Research21 Jan 2015
Nature Communications

Volume: 6, P: 1-11
Dithiol amino acids can structurally shape and enhance the ligand-binding properties of polypeptides

Disulfide bonds formed between two cysteine residues are important in the folding and stability of proteins. Now, unnatural amino acids with side-chains that contain two thiol groups are described. Incorporation of these dithiol amino acids into a serine protease inhibitor and a nicotinic acetyl choline receptor antagonist is shown to increase their inhibitory activity.

Shiyu Chen
Ranganath Gopalakrishnan
Christian Heinis
Research31 Aug 2014
Nature Chemistry

Volume: 6, P: 1009-1016
Structural and functional dissection of the DH and PH domains of oncogenic Bcr-Abl tyrosine kinase

The Bcr-Abl tyrosine kinases p210 and p190 are linked to different leukemias and differ by the Dbl homology (DH) and Pleckstrin-homology (PH) domains. Here the authors characterize structures of the Bcr-Abl p210 DH and PH domains and find that the PH domain is important for the cellular localization and signaling network of p210.

Sina Reckel
Charlotte Gehin
Oliver Hantschel
ResearchOpen Access13 Dec 2017
Nature Communications

Volume: 8, P: 1-14
Evolution of the chalcone-isomerase fold from fatty-acid binding to stereospecific catalysis

The diffusion limited stereospecific enzyme chalcone isomerase represents the adaptive evolution of a catalytically perfected enzyme from non-catalytic, fatty-acid-binding proteins (FAPs) with contemporary roles in plant fatty-acid metabolism as evidenced by altered fatty acid content and marked reproductive defects in Arabidopsis thaliana plants bearing FAP knockouts.

Micheline N. Ngaki
Gordon V. Louie
Joseph P. Noel
Research13 May 2012
Nature

Volume: 485, P: 530-533
SaccharomycesIDentifier, SID: strain-level analysis of Saccharomyces cerevisiae populations by using microsatellite meta-patterns

Irene Stefanini
Davide Albanese
Claudio Donati
ResearchOpen Access10 Nov 2017
Scientific Reports

Volume: 7, P: 1-10

Search

Construction of dual-cofactor artificial metalloenzymes for synergistic and enantiodivergent catalysis of Michael addition reactions

Discovery and characterization of a marine bacterial SAM-dependent chlorinase

Pyridomycin bridges the NADH- and substrate-binding pockets of the enoyl reductase InhA

Antibody–peptide conjugates deliver covalent inhibitors blocking oncogenic cathepsins

High-affinity peptides developed against calprotectin and their application as synthetic ligands in diagnostic assays

Lansoprazole is an antituberculous prodrug targeting cytochrome bc₁

Patient-derived monoclonal antibody neutralizes SARS-CoV-2 Omicron variants and confers full protection in monkeys

Btk SH2-kinase interface is critical for allosteric kinase activation and its targeting inhibits B-cell neoplasms

Palmitoylated acyl protein thioesterase APT2 deforms membranes to extract substrate acyl chains

Selective inhibition of STAT3 signaling using monobodies targeting the coiled-coil and N-terminal domains

De novo development of proteolytically resistant therapeutic peptides for oral administration

Author Correction: Internalization and vacuolar targeting of the brassinosteroid hormone receptor BRI1 are regulated by ubiquitination

A rheostat mechanism governs the bifurcation of carbon flux in mycobacteria

Internalization and vacuolar targeting of the brassinosteroid hormone receptor BRI1 are regulated by ubiquitination

Dithiol amino acids can structurally shape and enhance the ligand-binding properties of polypeptides

Structural and functional dissection of the DH and PH domains of oncogenic Bcr-Abl tyrosine kinase

Evolution of the chalcone-isomerase fold from fatty-acid binding to stereospecific catalysis

SaccharomycesIDentifier, SID: strain-level analysis of Saccharomyces cerevisiae populations by using microsatellite meta-patterns

Search

Quick links

Search

Filter By:

Search

Quick links