Haptoglobin (Hp) scavenges cell-free haemoglobin and is associated with the prognosis of human sepsis. Here, the authors characterize the association of fucosylated Hp in sepsis progression and identify a macrophage population expressing a receptor for fucosylated Hp, highlighting its inflammation-amplifying effects in in vitro human cell cultures and in vivo using a mouse model.
- Taylor Roh
- Sungeun Ju
- Eun-Kyeong Jo
