The Orai1 Ca2+ channel is activated by STIM1 in response to Ca2+ release from the ER. Here Maléth et al.show that Orai1 inactivation occurs by translocation to PI(4,5)P2-rich plasma membrane microdomains, which facilitates recruitment of SARAF, a negative regulator of STIM1 function.
- Jozsef Maléth
- Seok Choi
- Malini Ahuja
