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Showing 1–6 of 6 results

Advanced filters: Author: Miwako Kakiuchi Clear advanced filters

Bone marrow niches orchestrate stem-cell hierarchy and immune tolerance

Previously undescribed hierarchical arrangements in haematopoietic stem cells and their niches that mediate both regenerative potential and immune privilege are identified.

Kazuhiro Furuhashi
Miwako Kakiuchi
Joji Fujisaki
Research01 Jan 2025
Nature

Volume: 638, P: 206-215
Gut insulin action protects from hepatocarcinogenesis in diabetic mice comorbid with nonalcoholic steatohepatitis

Diabetes is known to increase the risk of nonalcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC). Here, the authors show in a mice model that insulin action in the gut may play a protective role in the development of NASH and HCC in diabetes.

Kotaro Soeda
Takayoshi Sasako
Kohjiro Ueki
ResearchOpen Access18 Oct 2023
Nature Communications

Volume: 14, P: 1-18
Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I

Inhibition of the autophagy–lysosome system upregulates surface expression of MHC class I proteins and enhances antigen presentation, and evokes a potent anti-tumour immune response that is mediated by CD8⁺ T cells.

Keisuke Yamamoto
Anthony Venida
Alec C. Kimmelman
Research22 Apr 2020
Nature

Volume: 581, P: 100-105
Generation of functional lungs via conditional blastocyst complementation using pluripotent stem cells

Pluripotent stem cells can generate functional lungs when injected into blastocyst-stage mouse embryos, a step toward the goal of growing human lungs in large animals for disease modeling and therapeutic applications.

Munemasa Mori
Kazuhiro Furuhashi
Wellington V. Cardoso
Research07 Nov 2019
Nature Medicine

Volume: 25, P: 1691-1698
Recurrent gain-of-function mutations of RHOA in diffuse-type gastric carcinoma

Shumpei Ishikawa and colleagues report the identification of recurrent gain-of-function mutations in RHOA in diffuse-type gastric carcinomas.

Miwako Kakiuchi
Takashi Nishizawa
Shumpei Ishikawa
Research11 May 2014
Nature Genetics

Volume: 46, P: 583-587
Registered multi-device/staining histology image dataset for domain-agnostic machine learning models

Mieko Ochi
Daisuke Komura
Shumpei Ishikawa
ResearchOpen Access03 Apr 2024
Scientific Data

Volume: 11, P: 1-13