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Engineering functional soft tissue constructs remains difficult due to mechanical, physicochemical, and biological requirements. Here, the authors report on a gyroid scaffold design that promotes capillary network formation and enables production of vascularised 3D models and soft tissue engineering scaffolds.

O3-type sodium anion-redox cathodes show promise but are hard to synthesize due to unclear mechanisms. Here, authors elucidate the role of oxygen conditions, enabling O3-Na[Li_1/3Mn_2/3]O₂ synthesis and developing Ti-substituted with capacities >190 mAh·g^-1.

Self-assembled monolayers struggle to uniformly coat textured surfaces, limiting high-efficiency perovskite and silicon tandem solar cells. Du et al. increase surface hydroxyl groups by incorporating carbon into polysilicon, enabling stable monolayer attachment and record device efficiency.

Immune checkpoint therapy (ICT) offers durable cancer control but is limited by resistance. This study shows that deleting miR-25 enhances ICT by activating innate and humoral immunity, remodeling CAF and macrophage interactions.

This study finds that the most dangerous tick-borne viruses infect many tick and animal species, boosting their chances of reaching humans. Bird migration helps spread them worldwide, and genetic adaptation may increase their ability to infect people.

Electrosynthesis of 1,3-butadiene from dilute coal-derived acetylene is promising yet remains challenging due to competing side reactions. Here, the authors develop coordination-modulated dicopper molecular catalysts to steer the electrocatalytic dilute acetylene toward 1,3-butadiene.

Conventional Si-based physical unclonable functions (PUFs) are normally limited by limited entropy and lack of reconfigurability, exposing them to machine learning attacks. Here, the authors report optically reconfigurable PUFs based on 2D MoS₂ ring-oscillator arrays, demonstrating machine-learning-attack-resistant image encryption.

This study establishes the link between epithelial zinc transporter SLC39A1 and acute lung injury. The authors uncover a protective mechanism in lung epithelium mediated by the SLC39A1-zinc-autophagy axis and highlight SLC39A1 as a potential therapeutic target.

This study reveals how plants balance growth with survival under low-oxygen conditions. The signaling module SnRK1–RAP2.4h–PIP2 fine-tunes this trade-off, offering a potential target to improve crop flood tolerance.

This study found that severe fever with thrombocytopenia syndrome increased in Anhui, China in 2019–2023 and was highest in central and southern areas. Farmers and older adults were most affected, peaking in spring to early autumn.

Whilst it is known that host ribosomal protein SA (RPSA) regulates the anti-infection immunity in immune cells, its role in neutrophil migration is yet to be explored. In this work, authors provide mechanistic insight into the impact of RPSA on promoting neutrophil migration via the regulation of olfactomedin 4 (OLFM4), in the context of sepsis.

Low-dose IL-2 therapy has been evaluated for the treatment of numerous autoimmune conditions. This study reports the outcomes of a phase 2, randomised, placebo-controlled trial evaluating the efficacy and safety of low-dose IL-2 for the treatment of systemic lupus erythematosus (SLE).

Hypothalamic POMC neurons are critical for energy balance. Here, authors show that TOX3 in these neurons regulates metabolism by promoting PTEN degradation and AKT activation, enhancing thermogenesis to protect against obesity.

CO₂ electroreduction is promoted by alkali cations in the electrolyte, but the precise mechanism by which this occurs is not clear. Now in situ infrared spectroscopy and ab initio molecular dynamics are combined to elucidate the specific role of alkali cations and their trends.

Part of the Hong Kong Genome Project, genomic analyses of more than 20,000 participants provide information on clinically relevant variants for the Chinese population and offer insights on the implementation of genomic medicine initiatives.

Conventional slurry electrodes limit high-energy lithium batteries. This work shows that dry-processed electrodes with molecularly coupled carbon–binder networks enable high mass and active material loading, supporting stable high-voltage operation and enhancing battery energy density.

Organic solar cells need acceptor molecules with long exciton diffusion lengths, but most available materials fail in thick films. The authors design new fluorinated quinoxaline acceptors that significantly improve carrier mobilities resulting in superior efficiency in both binary and ternary devices.

Li et al. conduct a multi-omics analysis of nasopharyngeal carcinoma and identify three molecular subtypes with distinct immune profiles and responses to induction chemotherapy.

This study reveals that TOPOISOMERASE1 ALPHA inhibits lateral root primordium initiation in Arabidopsis by stabilizing a DNA G-quadruplex in CYP82C4, uncovering an epigenetic control over the reprogramming of pericycle cells into stem cells.

A modular peptide technology that self-assembles into nanofibres on bacterial surfaces through a membrane-anchoring biphenyl group, a diphenylalanine linker and a cationic peptide enables disruption of drug-resistant pathogens.

This study demonstrates how CO₂ directs defect control during the synthesis of Mn-rich sodium layered oxides, improving the stability and performance of earth-abundant positive electrode materials in non-aqueous sodium-based rechargeable batteries.

Thermogenic adipocytes are a potential therapy to combat obesity, although the process underlying their activation remains unclear. Here, the authors use epigenetic profiling to demonstrate RUNX1 and RUNX2 inhibit thermogenesis by distinct mechanisms.

Global Burden of Disease analysis found that in 2023, suboptimal diet was estimated to be responsible for 4 million deaths and 97 million morbidity burdens from ischemic heart disease.

Arginine addiction induced by argininosuccinate synthase (ASSN1) deficiency has been exploited to treat ASS1-deficient cancers. Here, the authors show an alternative therapeutic approach where ASS1 activity is increased by the pesticide spinosyn A and is shown to inhibit breast cancer cell proliferation.

Artificial synapses for wearable and implantable applications are limited in widespread use due to environmental instability, limited ion-trapping capabilities and high energy consumption. Here, the authors present a biodegradable multilayer artificial synapse achieving 0.85 fJ per synaptic event.

PRIME-In couples a prime edited donor template with either single or paired genomic nicks to enable precise integration of even large constructs into human cells, as exemplified by high-efficiency integration of a 3-kb CAR construct in T cells.

CAR-M therapy shows promise for liver fibrosis but limited anti-inflammatory activity reduces efficacy. Here the authors show that TRIM13-engineered, FAP-targeted CAR macrophages sustain anti-inflammatory function and reduce liver fibrosis in mice.

A miniaturized and low-power-consumption system is designed to allow the accurate sensing and wireless transmission of internal temperature and strain signals inside lithium-ion batteries with negligible influence on their performance, improving their safety.

In this study, the authors identify a microcircuit containing three subgroups of neurons associated with sensory-induced escape in the mouse temporal association cortex (TeA): sensory, sensory-motor decision and motor command neurons.

Measurement-based quantum computing implements quantum algorithms by performing sequences of measurements on special classes of entangled states, such as cluster states. This approach has now been demonstrated on a superconducting quantum processor.

This work presents DeepSeMS, a transformer-based framework that translates biosynthetic gene clusters into candidate secondary metabolite structures, enabling scalable exploration of chemical diversity from uncultivated global ocean microbiomes.

Tailored non-aqueous electrolyte solutions are formulated using data obtained from extensive analytical measurements and analyses. These optimized electrolytes improve the cycling performance of single-layer stack lithium metal pouch cells, particularly in lean electrolyte conditions.

In this study, the authors present two distinct neuronal subpopulations, sharing a speed encoding model, in the mouse dorsal periaqueductal grey, controlling running and backing away behaviors, respectively.

Lattice strain impacts battery cathode performance and cycle life. Here, authors visualize and quantify strain in layered oxides through electron backscatter diffraction imaging, revealing heterogeneous, cycle-dependent distortions that slow Li transport and limit capacity, with irreversible layer bending driving capacity fade.

Analyses of whole-genome sequencing data in children and validation in mouse models show that offspring born from blastocyst-stage embryo transfer have shorter leukocyte telomere lengths.

Interlayer spacing and termination are important for controlling the physical and chemical properties of MXenes, largely affecting their potential applications. Here authors present a general approach for simultaneously tuning the interlayer spacing and termination of MXenes using Lewis-basic halides.

Development of efficient upconversion (UC) phosphors that emit under irradiation in the NIR II region is challenging - most UC materials rely on the presence of sensitizers absorbing at shorter wavelengths. Here, authors synthesize Er³⁺ doped ternary sulfides phosphors with visible UC efficiency up to 2.6% and long emission lifetimes under 1532 nm irradiation, via an excited state absorption mechanism.

Freestanding membranes of hexagonal oxides remain difficult to obtain. In this work, a water-soluble crystalline hexagonal BaAl₂O₄ is found to serve as a sacrificial layer for obtaining freestanding membranes with six-fold or three-fold symmetry.

RORγt⁺ antigen-presenting cells (APC) are playing a role in the generation of oral tolerance via their interaction with regulatory T cells recognising dietary and commensal bacterial antigens. Here authors show that a cis transcriptional regulatory element is responsible for RORγt specifically in APCs through interaction with RUNX3 and formation of chromatin loops, which determines a transcriptional program that distinguishes these oral tolerance mediating APCs from RORγt⁺ T cells.